The University of Iowa

Clinical Islet Transplantation Consortium



The Clinical Islet Transplantation (CIT) Consortium, jointly supported by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) and the National Institute of Allergy and Infectious Diseases (NIAID), was a network of clinical centers and a data coordinating center established in 2004 to conduct studies of islet transplantation in patients with type 1 diabetes. The CTSDMC was the data coordinating center for this 14-year project. 

The primary goal of CIT was to improve the efficacy of pancreatic isolation, purification, and transplantation into patients with Type 1 Diabetes so that the clinical sites could submit their own Biologics Licennse Applications to manufacture the islet product. This resulted in the design and successful implementation of 8 protocols, plus the development of a Master Production Batch Record. 

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