CTSDMC Projects Past and Present

  • Trial of Org10172 in Acute Stroke Treatment (TOAST)

    1990-1998

    The first large multi-center trial to be managed by the CTSDMC.

  • Efficacy of Acetyl-L-Carnitine in Patients with Alzheimer's Disease

    1990-1991

  • The International Study of Unruptured Intracranial Aneurysms (ISUIA I & ISUIA II)

    1991-2001

  • Health Assessment of Persian Gulf War Veterans from Iowa

    1994-1997

  • The Effect of Irbesartan on Renal Events and All-Cause Mortality in Patients with Diabetic Nephropathy Due to Type II Diabetes

    1996-1999

  • Intraoperative Hypothermia for Aneurysm Surgery Trial 2 (IHAST2)

    1999-2006

  • Comparison of Language Intervention Programs (CLIP)

    2001-2005

  • Clinician-Managed Interpersonal Psychotherapy (CMIPT)

    2001-2006

  • Carotid Occlusion Surgery Study (COSS)

    2001-2012

  • Cognitive Functioning After Aneurysm Surgery (CFAAST)

    2003-2005

  • The International Study of Unruptured Aneurysms (ISUIA III)

    2004-2008

  • Clinical Islet Transplantation (CIT)

    2004-2017

  • Randomized Evaluation of Carotid Occlusion and Neurocognition (RECON)

    2004-2012

  • Bracing In Adolescent Idiopathic Scoliosis (BrAIST)

    2006-2013

  • Placebo Controlled Trial of Setraline and IPT for Postpartum Depression (ZIP)

    2007-2014

  • A Collaborative Model to Improve BP Control and Minimize Racial Disparities (CAPTION)

    2009-2014

  • The Streptococcus Mutans in Lakota Sioux Study (SMILeS)

    2010-2013

  • The Parkinson's Progression Markers Initiative Statistical Core (PPMI Stat Core)

    2010-Present

  • Amitryiptyline and Topiramate in the Prevention of Childhood Migraine (CHAMP)

    2011-2017

  • Network of Excellence in Neuroscience Clinical Trials (NeuroNEXT) - DCC

    2011-Present

  • NN101- SMA Biomarkers in the Immediate Post-Natal Period of Development (Super Baby)

    2012-2016

  • NN102- Idubilast in Phase II Trial in Progressive MS (SPRINT-MS)

    2013-2020

  • NN103- A Phase II Trial of Rituximab in Myasthenia Gravis (BeatMG)

    2013-2019

  • NN104- Safety Evaluation of 3K3A-APC in Ischemic Stroke (RHAPSODY)

    2014-2018

  • Medication Focused Outpatient Care for Underutilization of Secondary Prevention (MEDFOCUS)

    2014-2022

  • Enhancing Scientific Inquiry in Clinical Neurosciences Through Methodology Training

    2014-2022

  • NN105- Tolerability of SRX246 in Huntington's Disease Patients (Stair)

    2015-2018

  • Systemic Synuclein Sampling Study (S4)

    2015-2019

  • NN106- Cytochrome C Oxidase: Biomarker in Newly Diagnosed Glioblastoma Multiforme (Cyto-C)

    2016-2022

  • NN107- Effects of AFQ056 on Language Learning in Young Children with Fragile X Syndrome (FX Learn)

    2016-2023

  • NN108- Topiramate as a Disease Altering Therapy for CSPN (TopCSPN)

    2017-2023

  • NN109- Efficacy of ManNAc in Subjects with GNE Myopathy (MAGINE)

    2017-Present

  • Safety of the Chronic Administration of Nilotinib in Patients with Parkinson's Disease (NILO-PD)

    2017-2020

  • NN110- A Dose Selection Trial of Light Therapy for Impaired Sleep in Parkinson's Disease (Enlite PD)

    2019-2024

  • Acute to Chronic Pain Signature Program (A2CPS)

    2019-Present

  • Fibromyalgia Transcutaneous electrical nerve stimulation (TENS) in Physical Therapy Study (FM-TIPS)

    2019-Present

  • NN111- Evaluate the Activity and Safety of Inebilizumab in Anti-N-Methyl-D-Aspartate Receptor (NMDAR) Encephalitis (ExTINGUISH)

    2021-Present

  • The Parkinson's Progression Markers Initiative Data Management Core (PPMI DMC)

    2022-Present

  • E-Health Behavioral Intervention to Improve Executive Functioning in Adolescents with Epilepsy (EJ 2.0)

    2024-Present

  • The Path to Prevention (P2P) Platform Trial Statistics Core (P2P Stat Core)

    2024-Present

  • The Path to Prevention (P2P) Platform Trial Data Management Core (P2P DMC)

    2024-Present

  • Effectiveness and Tolerability of Oral Migraine Preventive Medications (APT Comparison)

    2025-Present